KPNA3, karyopherin subunit alpha 3, 3839

N. diseases: 20; N. variants: 2
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 AlteredExpression group BEFREE Overexpression of KPNA3 in HCC cells enhanced tumor cell growth and invasiveness. 31417635 2019
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma 		0.010 Biomarker disease BEFREE Targeting KPNA3 may also contribute to resolving sorafenib resistance in HCC. 31417635 2019
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.010 AlteredExpression disease BEFREE The aim of the present study was to measure the level of microRNA (miRNA or miR)-24 in the serum of patients with atherosclerosis and to investigate the effect of miR-24 on the expression of importin-α3 and tumor necrosis factor (TNF)-α, as well as the proliferation and migration of vascular endothelial cells. 29250154 2018
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.010 AlteredExpression disease BEFREE The aim of the present study was to measure the level of microRNA (miRNA or miR)-24 in the serum of patients with atherosclerosis and to investigate the effect of miR-24 on the expression of importin-α3 and tumor necrosis factor (TNF)-α, as well as the proliferation and migration of vascular endothelial cells. 29250154 2018
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 AlteredExpression disease BEFREE Increased expression of DLEU1 and KPNA3 was observed in human CRC tissues. 30098595 2018
CUI: C0024408
Disease: Machado-Joseph Disease
Machado-Joseph Disease 		0.010 Biomarker disease BEFREE Since KPNA3 is known to function as an import protein and recognize nuclear localization signals (NLSs), this work unites ataxin-3 structure to the nuclear pore machinery and provides a link between karyopherins, NLS signals, and polyglutamine disease, as well as demonstrates that KPNA3 is a key player in the pathogenesis of SCA3. 29476013 2018
CUI: C0265218
Disease: Neu-Laxova syndrome
Neu-Laxova syndrome 		0.010 Biomarker disease BEFREE Since KPNA3 is known to function as an import protein and recognize nuclear localization signals (NLSs), this work unites ataxin-3 structure to the nuclear pore machinery and provides a link between karyopherins, NLS signals, and polyglutamine disease, as well as demonstrates that KPNA3 is a key player in the pathogenesis of SCA3. 29476013 2018
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 Biomarker phenotype BEFREE DLEU1 knockdown remarkably inhibited CRC cell proliferation, migration and invasion in vitro and in vivo while overexpressing KPNA3 in the meantime reversed it. 30098595 2018
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.010 AlteredExpression disease BEFREE LncRNA DLEU1 contributes to colorectal cancer progression via activation of KPNA3. 30098595 2018
CUI: C0243010
Disease: Viral Encephalitis
Viral Encephalitis 		0.010 Biomarker group BEFREE These results suggest that JEV NS5 inhibits the induction of type I IFN by targeting KPNA3 and KPNA4.<b>IMPORTANCE</b> JEV is the major cause of viral encephalitis in South and Southeast Asia, with high mortality. 28179530 2017
CUI: C4277690
Disease: Ciliopathies
Ciliopathies 		0.010 GeneticVariation disease BEFREE Using a panel of skeletal dysplasias genes, including 11 related to SRP, we identified biallelic mutations in IFT122 ([c.3184G>C];[c.3228dupG;c.3231_3233delCAT]) in a fetus with a typical phenotype of SRP-IV, finally confirmed that this phenotype is a ciliopathy and adding to the list of ciliopathies with major skeletal involvement. 28370949 2017
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease PSYGENET Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders. 22960338 2012
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.330 Biomarker disease BEFREE Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders. 22960338 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 Biomarker disease PSYGENET KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C0001973
Disease: Alcoholic Intoxication, Chronic
Alcoholic Intoxication, Chronic 		0.310 GeneticVariation disease BEFREE KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 GeneticVariation disease BEFREE KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.310 Biomarker disease PSYGENET Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. 22960338 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.310 GeneticVariation disease BEFREE KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder 		0.310 Biomarker disease PSYGENET Using a haplotype block-based gene-tagging approach we genotyped six KPNA3 single nucleotide polymorphisms (SNPs) in 157 schizophrenia patients, 121 post-traumatic stress disorder patients, 120 opiate dependent patients, 231 alcohol dependent patients, 147 nicotine dependent patients and 266 major depression patients. 22960338 2012
CUI: C1629609
Disease: Age at menopause
Age at menopause 		0.100 GeneticVariation phenotype GWASDB Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 22267201 2012
CUI: C1629609
Disease: Age at menopause
Age at menopause 		0.100 GeneticVariation phenotype GWASCAT Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways. 22267201 2012
CUI: C0004936
Disease: Mental disorders
Mental disorders 		0.010 Biomarker group BEFREE Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders. 22960338 2012
CUI: C0233514
Disease: Abnormal behavior
Abnormal behavior 		0.010 Biomarker phenotype BEFREE Our study suggests that KPNA3 may contribute to the genetic susceptibility to schizophrenia as well as other psychiatric disorders. 22960338 2012
CUI: C0524662
Disease: Opiate Addiction
Opiate Addiction 		0.010 GeneticVariation disease BEFREE KPNA3 variation is associated with schizophrenia, major depression, opiate dependence and alcohol dependence. 22960338 2012
CUI: C0021400
Disease: Influenza
Influenza 		0.010 Biomarker disease BEFREE KPNA3 and RANBP5 control the nuclear import of the influenza virus. 18552348 2009